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This fungal pathogen invades nearly all parts of plants including stems, leaves, flowers, fruits, and seeds at both pre-harvest and post-harvest stages. Due to its wide host range and the huge economic losses that it causes, extensive investigations have been carried out to effectively control this plant pathogen. It is beneficial for exploring the pathogenic mechanisms of B. In recent years, tremendous progress has been made in understanding these pathogenic genes and regulatory pathways, as well as the control strategies of B.

Here, the current knowledge will be summarized in this review. Botrytis cinerea is one of the most extensively studied necrotrophic fungal pathogens and causes gray mold rot in more than plant species Williamson et al.

This pathogen has a disastrous economic impact on various economically important crops including grape, strawberry, and tomato Dean et al. It may trigger obvious disease symptoms in the pre-harvest period or remain quiescent until post-harvest period Fillinger and Elad, Botrytis cinerea has been reckoned as one of the most important post-harvest pathogens in fresh fruits and vegetables Zhang et al. The annual economic losses of B. Due to its scientific and economic importance, B.

It is difficult to control B. The asexual spores of B. To date, the principal means to control grey mold rot caused by B. However, the control effects of fungicides are not satisfactory on B. In addition, fungicides are not safe for human and environment Droby et al. Therefore, it is important to deeply understand the molecular basis of pathogenesis of B. In recent years, great efforts have been put on exploring the molecular mechanisms of B.

In this review, we mainly introduce the latest information about molecular pathogenesis of B. Reactive oxygen species ROS are a collective of highly reactive molecules including superoxide anion. OH , and certain non-radical oxidizing agents such as hydrogen peroxide H 2 O 2 and ozone O 3 that can be converted into radicals.